Mes/Stem-A ovarian cancer subtypes predict sensitivity to ATR inhibition
Sundararajan V, Fang Z, Elfar GA, Tan TZ, ... Cheok CF, Tan DSP
Oncogene
Publications
Selected publications from the lab. For the full list, visit our Google Scholar profile.
See Google Scholar for up-to-date citation metrics.
2026
Frequent novel viral focal copy number gains potentiate radiosensitivity in natural killer/T-cell lymphoma
Lim JQ, Phyu T, Huang D, Phang BH, Fang Z, ... Cheok CF, Ng SB, Ong CK
Cancer Communications
2025
Cell migration in endometriosis responds to omentum-derived molecular cues similar to ovarian cancer
Goh KY, Tham SC, Cheng TYD, ... Cheok CF, Lim DWT, Lim EH
Int. J. Mol. Sci.
2024
p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis
Elfar GA, Aning O, Ngai TW, Yeo P, Chan JWK, Sim SH, Goh L, ... Cheok CF
Nucleic Acids Research
PHF2 regulates genome topology and DNA replication in neural stem cells via cohesin
Feng J, Chuah YH, Liang Y, Cipta NO, ... Cheok CF, Ong DST
Nucleic Acids Research
2021
Nitro-deficient niclosamide confers reduced genotoxicity and retains mitochondrial uncoupling activity for cancer therapy
Ngai TW, Elfar GA, Yeo P, Phua N, Hor JH, Chen S, Ho YS, Cheok CF
Int. J. Mol. Sci.
2020
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
Kong LR, Ong RW, Tan TZ, ... Cheok CF et al.
Nature Communications
2019
2018
Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
Kumar R, Coronel L, Somalanka B, Raju A, Aning OA, ... Cheok CF
Nature CommunicationsFeatured in A*STAR Research Highlights
2017
Dynamics of RIF1 SUMOylation is regulated by PIAS4 in the maintenance of genomic stability
Kumar R, Cheok CF
Scientific Reports
Cyclin-dependent kinase-dependent phosphorylation of Sox2 at serine 39 regulates neurogenesis
Lim S, Bhinge A, Bragado Alonso S, ... Cheok CF, ...
Molecular and Cellular Biology
2016
p53 maintains genomic stability by preventing interference between transcription and replication
Yeo CQX, Alexander I, Lin Z, Lim S, Aning OA, Kumar R, ... Cheok CF
Cell ReportsHighlighted in Nature Reviews Molecular Cell Biology
2014
RIF1: a novel regulatory factor for DNA replication and DNA damage response signaling
Kumar R, Cheok CF
DNA Repair
2012
Seeking synergy in p53 transcriptional activation for cancer therapy
Cheok CF, Lane DP
Discovery Medicine
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
Coffill CR, Muller PA, Oh HK, Neo SP, ... Cheok CF, Vousden KH, Lane DP, Blackstock WP, Gunaratne J
EMBO Reports
2011
Translating p53 into the clinic
Cheok CF, Verma CS, Baselga J, Lane DP
Nature Reviews Clinical Oncology
New insights into p53 based therapy
Lane DP, Brown CJ, Verma C, Cheok CF
Discovery Medicine
Reactivation of p53: from peptides to small molecules
Brown CJ, Cheok CF, Verma CS, Lane DP
Trends in Pharmacological Sciences
2010
Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53
Cheok CF, Kua N, Kaldis P, Lane DP
Cell Death & Differentiation
The Mdm2 and p53 genes are conserved in the Arachnids
Lane DP, Cheok CF, Brown CJ, Madhumalar A, Ghadessy FJ, Verma C
Cell Cycle
Mdm2 and p53 are highly conserved from placozoans to man
Lane DP, Cheok CF, Brown C, Madhumalar A, Ghadessy FJ, Verma C
Cell Cycle
2009
WIP1 phosphatase is a negative regulator of NF-κB signalling
Chew J, Biswas S, Shreeram S, ... Cheok CF, López-Collazo E, Bulavin DV, Tergaonkar V
Nature Cell Biology
2008
New developments in small molecules targeting p53 pathways in anticancer therapy
Cheok CF, Lane DP
Drug Development Research
R-Roscovitine simultaneously targets both the p53 and NF-κB pathways and causes potentiation of apoptosis: implications in cancer therapy
Dey A, Wong ET, Cheok CF, Tergaonkar V, Lane DP
Cell Death & Differentiation
2007
Cyclin-dependent kinase inhibitors sensitize tumor cells to nutlin-induced apoptosis
Cheok CF, Dey A, Lane DP
Molecular Cancer Research
Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6
Camus S, Menéndez S, Cheok CF, Stevenson LF, Laín S, Lane DP
Oncogene
2005
The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA
Cheok CF, Wu L, Garcia PL, Janscak P, Hickson ID
Nucleic Acids Research
Roles of the Bloom's syndrome helicase in the maintenance of genome stability
Cheok CF, Bachrati CZ, Chan KL, Ralf C, Wu L, Hickson ID
Biochemical Society Transactions