IMCB, A*STAR & NUS Pathology
Impacting Science
We identify bottlenecks in cancer signalling pathways and design new therapeutic targets that counteract the growth of cancer cells, focusing on drug and RNAi therapeutics in the DNA damage and metabolic pathways.
We believe in empowering the individual, and growing our next generation of scientists.
Research Highlights
Our work spans fundamental cancer biology to translational therapeutic development.
Molecular Vulnerabilities in Cancer
Identifying molecular vulnerabilities in cancers through DNA damage response networks and cellular metabolism.
Novel Therapeutics
Developing novel therapeutics through in silico and structure-activity relationship (SAR) studies.
Molecular Signatures & Drug Response
Identifying molecular signatures predicting drug response through gene network analysis.
Recent Work
Highlighted publications from the lab
p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis
Nucleic Acids Research
Nitro-deficient niclosamide confers reduced genotoxicity and retains mitochondrial uncoupling activity for cancer therapy
Int. J. Mol. Sci.
Drugging in the absence of p53
Journal of Molecular Cell Biology
Collaborative Opportunities
We are open to collaborative opportunities in:
DNA Replication & Damage Responses
DNA replication and damage responses in cells for therapeutic exploitation.
Mitochondrial Uncoupling
Manipulation of mitochondrial uncoupling in cells for neurodegenerative diseases and cancers.
Technical Expertise
Single-molecule DNA fiber labeling for tracking of DNA replication ex vivo and in vivo
Study of Mitochondrial Superoxide/reactive oxygen species and cellular ROS status
Study of calcium fluxes in cells using live cell imaging and molecular inhibitors/activators
Monitoring of mitochondrial and cellular respiration
About Our Lab
Get a glimpse into our research and lab culture.